20 February 2023
A Bio-photoelectrolytic Organic Semiconductor Platform For Measurement And Control Of Proliferation And Behaviour Of Living Cells Using Light Pulses
Organic semiconductors have been shown to be promising for interfacing with biological systems because they are biocompatible, printable and their optical properties can be tailored. A multidisciplinary international team from seven research institutes have designed a bio-photoelectrolytic platform based on semiconducting polymer thin films, onto which cells were cultured immersing both in an aqueous biological medium. The team demonstrated it is possible to inhibit cell proliferation by 50% in a cancer cell line by subjecting the platform to a series of light pulses over time. Light stimulation was found to increase the concentration of calcium ions inside the cells by three times. The platform also enabled to measure bio-electrical signals. The bio–photoelectrolytic platform and the effective use of light stimulation may open new avenues for in vitro light control/manipulation of cell behaviour, for the development of future novel non-invasive tools for application in bio-sensing, regenerative medicine and cell-based therapy, and for cancer progression control and therapy.
Results are published in Advanced NanoBiomed Research, 2200127 (2023)
https://onlinelibrary.wiley.com/doi/full/10.1002/anbr.202200127
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